How to Handle a Variant of Uncertain Significance

Description
This webinar will cover the basics of genetic testing and how results are interpreted, with a focus on variants of uncertain significance (VUS). We will review was VUSs are, why they occur, and their impact on clinical management. Attendees will learn how to identify key information in genetic reports, understand current management recommendations for VUSs, and explore available resources for clinicians. We will also cover steps to take when there are concerns about a VUS. Finally, we will examine the history and future of variant interpretation highlighting advancements in research, population databases, functional studies, and emerging technologies.

Level of Instruction
Basic - Entry level; no prior knowledge of subject necessary

Learning Objectives

  1. Define what a variant of uncertain significance (VUS) is and summarize the key factors involved in variant interpretation.
  2. Summarize management recommendations for VUS findings and how to approach concerns about a VUS.
  3. Examine how advances in research and technology are improving variant classification. 

Course summary

Available credit: 
  • 0.10 NSGC CEU
  • 1.00 PACE Contact Hour
Course opens: 
03/20/2025
Course expires: 
03/20/2025
Cost:
$0.00

Presenter: Caitlin Reid, MS, CGC

Genomic Science Liaison, Ambry Genetics

Caitlin joined Ambry Genetics in 2021 as the Oncology Genomic Science Liaison for the Midwest territory. In her current role, she serves as a clinical liaison for the field team to educate health care providers and key opinion leaders on genetic testing and genomic medicine. Caitlin previously worked as an Oncology Genetic Counselor at the University of Iowa in the Holden Comprehensive Cancer center. Caitlin received her Bachelor of Science degree in Biology with a concentration in cell and developmental biology from the University of Iowa. She earned her Master of Science degree in Genetic Counseling from the University of Michigan in 2018 and is certified by the American Board of Genetic Counseling.

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EducateNext is committed to providing independent, objective, and evidence-based educational content. None of the individuals in control of this content—including our planners, reviewers, and approval faculty—have any financial relationships with ineligible companies to disclose. For all educational sessions, speaker-specific disclosures regarding any potential conflicts of interest are required and will always be shared directly with learners at the beginning of their respective presentations.

Ambry Genetics is approved as a provider for continuing education program by NSGC and ASCLS P.A.C.E ® Programs.

 

Available Credit

  • 0.10 NSGC CEU
  • 1.00 PACE Contact Hour

Price

Cost:
$0.00
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Please note: Attendees must track continuing education (CE) credits towards recertification. Credit cannot be claimed for both live and recorded versions of the same webinar; attendance is cross-checked annually. We apologize for the inconvenience and are working toward a single-platform solution to automatically manage dual registration and integrated transcript tracking.